start:software:topical:lifesciences:ngs:local_search_tools

# Local Alignment Searches

Comparing primary biological sequence information, such as the amino-acid sequences of proteins or the nucleotides of DNA and/or RNA sequences is an integral part – not alone – of phylogenetics and metagenomics.

#### BLAST+

BLAST+ from the NCBI (National Center for Biotechnology Information) is the “canonical” implementation of a local alignment search tool, well established and maintained.

We provide this software as modules under:

bio/BLAST+

You can find a wrapper to ease your workflow, below.

#### BLAT

BLAT is a alternative implementation and long time competitor of BLAST+. Particularly, it strives to be faster than BLAST+.

We provide this software as modules under:

bio/BLAT

#### Diamond

Diamond is yet another implementation, restricted to protein sequences it is considerably faster the blastp.

We provide this software as modules under:

bio/DIAMOND

#### Lambda

Lambda claims to operate faster and in a compatible fashion compared to blastn/p/x

We provide this software as modules under:

bio/lambda – the application is lambda2

• start/software/topical/lifesciences/ngs/local_search_tools.txt